Photo of Professor Arup Chakraborty





人类有适应性免疫系统,这是显着的,因为它使我们能够安装病原体 - 抗病原体多样化和不断变化的世界具体的回应。我们集团的核心重点是了解的适应性免疫应答对病原体的机械基础,并利用这种理解来帮助设计更好的疫苗和疗法。我们的工作表示物理和生命科学的一个十字路口。适应性免疫反应是由集体动态过程与许多参与组件介导的。这些集体过程跨越秤的光谱,从分子到生物体(人类)的尺度,并在性质上固有地随机。我们在开发和应用的理论和计算方法(植根于统计物理学)来研究这些过程的工作。这些努力的一个特点是我们的理论/计算研究和领先的免疫学实验室实验研究之间,并且通过医学院校临床医生有着密切的协同与合作。当前利益可分为三大类。我们感兴趣的是理解的分子相互作用,使T细胞,适应性免疫应答的协调器,以便在对功能平移表面受体对病原体的接合。我们感兴趣的是T细胞如何发展,在胸腺导致T细胞的特异性针对未知的和新出现的病原体。我们在理解人体免疫应对艾滋病毒,与协助努力,设计的疫苗对这种祸害地球上的目标而努力。我们集团也有兴趣在细胞膜生物物理。

Arup K. Chakraborty is the 罗伯特·T·。化学工程,物理,化学和生物工程教授哈斯拉姆 at MIT. He is the founding Director of MIT’s Institute for Medical Engineering and Science. He is also a founding steering committee member of the Ragon Institute of MIT, MGH, and Harvard, and an Associate Member of the Broad Institute of MIT & Harvard. After obtaining his PhD in chemical engineering and postdoctoral studies, he joined the faculty at the University of California at Berkeley in December 1988. He rose through the ranks, and ultimately served as the Warren and Katherine Schlinger Distinguished Professor and Chair of Chemical Engineering, Professor of Chemistry, and Professor of Biophysics at Berkeley. He was also Head of Theoretical and Computational Biology at Lawrence Berkeley National Laboratory. In September 2005, Chakraborty moved to MIT. His entire career has been focused on research at the intersection of disciplines. After an early career in engineering of polymers and catalysts, since 2000, Chakraborty’s work has focused on bringing together immunology and the physical and engineering sciences; more specifically, the intersection of statistical mechanics and immunology. His interests span T cell signaling, T cell development and repertoire, and a mechanistic understanding of HIV evolution, antibody evolution, and vaccine design. Chakraborty’s work at the intersection of disciplines has been recognized by numerous honors, including the NIH Director’s Pioneer Award, the E.O. Lawrence Medal for Life Sciences from the US DOE, the Allan P. Colburn and Professional Progress awards from the AIChE, a Dreyfus Teacher-Scholar award, and a National Young investigator award. Chakraborty was elected a member of the National Academy of Sciences and the National Academy of Engineering for completely different bodies of work. He is also a member of the National Academy of Medicine, making him one of a small number of individuals who are members of all three branches of the US National Academies. He is a Fellow of the American Academy of Arts & Sciences and the American Association for the Advancement of Science, and serves on the US Defense Science Board. Chakraborty has received four teaching awards at Berkeley and MIT.